Connie J. Rogers, Ph.D.
Assistant Professor and Occupant of the Broadhurst Career Development Professorship for the Study of Health Promotion and Disease Prevention
224 Chandlee Laboratory
The Pennsylvania State University
University Park PA 16802
M.P.H., The University of Pittsburgh, 2003
Ph.D., The University of Pittsburgh, 1998
My research focuses on the role of changes in energy balance and related nutritional factors on inflammation, immune regulation and cancer risk using both animal models and human subjects. One focus area of the lab is to evaluate the biological impact of obesity on inflammatory mediators and anti-tumor immune mechanisms, and the downstream consequences of obesity-induced changes in immune processes on gastrointestinal and breast cancer incidence and development. A second focus area is to understand the mechanisms by which physical activity modulates immune function, and to determine if these changes impact cancer risk. In particular, we are interested in reducing the pro-inflammatory environment of obesity and reversing the obesity-induced deficits in anti-tumor immune mechanisms using physical activity, and gaining a better understanding of the biological mechanisms mediating these effects.
Rogers, C. J., Hance, K.W., Hursting, S.D., and Greiner J.G. 2007. Combination of nutrition, physical activity or other environmental factors and vaccine responses. Frontiers in Bioscience. 12: 5001-50029.
Hursting, S.D., Lashinger, L.M., Colbert, L.H., Rogers, C.J., Wheatley, K.W., Nunez, N.P, Mahabir, S., Barrett, J.C., Forman, M.R., Perkins, S.N. 2007. Energy balance and carcinogenesis: underlying pathways and targets for intervention. Curr Cancer Drug Targets. 7(5):484-91.
Rogers, C.J., Berrigan D., Zaharoff, D.A., Hance, K.W., Patel, A.C., Perkins, S.N., Schlom J., Greiner J.G., Hursting, S.D. 2008. Energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. J Nutr. 138: 115-122.
Rogers, C.J., Berrigan, D., Colbert, L.H., Greiner, J.W., Perkins, S.D., Hursting, S.D. 2008. Mechanisms linking physical activity and cancer prevention. Sports Medicine. 38(4):271-96
Rogers, C.J., Zaharoff, D.A., Hance, K.W., Perkins, S.N., Hursting, S.D., Schlom, J., Greiner, J.W. 2008. Exercise enhances vaccine-induced antigen specific responses. Vaccine. 26:5407-5415.
Hursting S.D., Lashinger L.M., Wheatley K.W., Rogers C.J., Colbert L.H., Nunez N.P., Perkins S.N. 2008. Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link. Best Pract Res Clin Endocrinol Metab. 22(4):659-69.
Rogers, C.J., Hance K.W., Sansbury, L.B., Albert, P.S., Murphy, G. A., Laiyemo, A.O., Wang, Z., Cross, A.J., Schatzkin, A., Lanza, E. Elevated serum TNFRI and TNFRII are associated with adenomatous polyp recurrence in women in the Polyp Prevention Trial. Cancer Epidem Biomarkers & Prev. (in press)
Bobe, G. Murphy, G., Rogers, C.J., Hance, K.W., Albert, P.S., Laiyemo, A., Sansbury, L.B., Lanza, E., Schatzkin, A., Cross, A.J. 2009. Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the Polyp Prevention Trial. Cancer Epidem Biomarkers & Prev. (in press)
Hursting , S.D., Rogers, C.J., Mahabir, S., Nunez, N.P., Barrett, J.C., Perkins, S.N., Forman, M.R. "Energy Balance and Cancer". In: Nutritional Oncology, 2nd Edition. D. Heber, G. Blackburn, V. Go, J. Milner, editors. Academic Press, Amsterdam, 2006, pp. 69-83.
Rogers, C.J., Hoffman-Goetz, L. 2009. "Cancer, Exercise & Immunity". In Encyclopedia of Lifestyle Medicine. (in press).
NUTR 445 Nutrient Metabolism I
NUTR 490W Nutrition Seminar